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VPE is using the Simple MAPI or Extended MAPI subsystem of the Windows operating system. Due to the design of both application interfaces, either subsystem is bound to the CPU architecture, for which your application is compiled / executed.

At the time of this writing, this means: the 64-bit version of your applications require a 64-bit mail client, and the 32-bit version of your applications require a 32-bit mail client.

Maybe Microsoft - or the developers of mail clients - will address this issue in a later version and provide bridging from one CPU architecture to the other.